Thursday, April 24, 2008

Muscular Diseases

Muscular dystrophies. These are a group of progressive genetic noninflammatory diseases characterized by muscle weakness and degeneration.

Duchenne muscular dystrophy is the most common type of MD. It is an x-linked inherited disease caused by a defect in the dystrophin gene which results in an absence of dystrophin.

Becker muscular dystrophy is a milder form of Duchenne MD. It is also due to a genetic defect in the dystrophin gene but the protein is still produced in an abnormal form.

Myositis is inflammation of the muscles.

Myositis can be a result of autoimmune reactions as in Dermatomyositis and Polymyositis.

Trichinella spiralis larva in a muscle cell

Myositis can also be caused by infection. Trichinosis is a parasitic worm infection of the muscles. It is commonly caused by eating undercooked pork.

Infection with anaerobic bacteria can also result in myositis.

Gangrene results when a wound becomes infected with the bacterium Clostridium perfringens.

Tetanus result from infection with the bacterium Clostridium tetani.

Myopathy is a term used to describe noninflammatory muscle diseases that are not muscular dystrophy.

Rhabdomyolysis is the breakdown of muscle fibers resulting in the release of myoglobin in to the circulation resulting in kidney damage.

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